Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2
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چکیده
منابع مشابه
Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).
Agmatine has received considerable attention recently. Available evidence suggests that agmatine functions as a neurotransmitter and inhibits, via induction of antizyme, cellular proliferation. Because of its positive charge, agmatine will not appreciably cross cellular membranes by simple diffusion. Indeed, all physiological models require a channel or transporter protein in the plasma membran...
متن کاملSelective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.
The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic amines. Using the Flp-in system, we expressed human PMAT (hPMAT) and human OCT3 (hOCT3) at similar levels in human embryonic kidney 293 cells. Parallel and detailed kinetics analysis revealed distin...
متن کاملKidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.
Human organic cation transporter 2 (OCT2/SLC22A2), which is specifically expressed in the kidney, plays critical roles in the renal secretion of cationic compounds. Tissue expression and membrane localization of OCT2 are closely related to the tissue distribution, pharmacological effects, and/or adverse effects of its substrate drugs. However, the molecular mechanisms underlying the kidney-spec...
متن کاملPharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).
Publications: Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, DeLaCruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, and Giacomini KM (2003) Natural variation in human membrane trasporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci (USA) 100:5896-5901. Leabman MD, Huang CC, Kawamoto M, Johns SJ, Stryke D...
متن کاملHistamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2.
Cellular reuptake of monoamines, which is mediated by cell membrane transporters, is followed by accumulation in vesicles by vesicular monoamine transporters (VMAT). The aim of this study was to demonstrate the presence of functional monoamine transporters with high affinity for histamine in human endometrial tissue, since histamine has been implicated as a paracrine signal during endometrial d...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.47.30915